In contrast, the CSD melanomas had a higher frequency of mutations than the nevogenic melanomas in NF1 (14/37, 37.8% vs. 6/82, 7.3%; p < 0.001), ROS1 (10/37, 27.0% vs. 4/82, 4.9%; p = 0.001), GNA11 (4/37, 10.8% vs. 1/82, 1.2%; p = 0.032), and RAC1 (6/37, 16.2% vs. 1/82, 1.2%; p = 0.004; Table 3; Figure 1; Figure S3). This evidence concerns the gene ROS1 and melanoma.