In addition, the Asian Cancer Research Group (ACRG) followed a different approach based primarily on gene expression profiling in a cohort of 300 Asian gastric cancer patients to identify four molecular subtypes: (i) microsatellite instable; (ii) microsatellite stable (MSS) TP53 inactive; (iii) MSS TP53 active, and iv) MSS with a gene expression profile related to Epidermal to Mesenchymal Transition (EMT). Here, TP53 is linked to cancer.