CELMoDs have an increased affinity to cereblon compared to IMiDs and, thus, the degradation of IKZF1 (Ikaros) and IKZF3 (Aiolos)—transcription factors essentials for MM cell survival—is increased, eventually leading to a greater antiproliferative effect [24] (Figure 1). The gene discussed is IKZF1; the disease is Miyoshi myopathy.