CCND1 and mantle cell lymphoma: This is in line with the fact that lymphoma cells interact with rosetting PD1-positive T cells in immunological synapses [21] and suggests, with respect to the lively motility observed in the PD1-positive rosetting T cells, a dynamic immunological synapse as previously described by Friedl et al. between T cells and dendritic cells [31] (also named a kinapse) [32] In contrast, MCL has strong activation of the cyclin D1 oncogene resulting from cyclin D1 translocation into one of the immunoglobulin gene loci, which makes it independent from the stimulation by TFH cells [33].