The same study showed that CHZ868 potently suppressed the growth of MHH-CALL4 leukemia cells with IC50 values in the range of 100 nM, while 1 μM of CHZ868 suppressed Jak2 phosphorylation, suggesting the involvement of other signaling pathways than Jak2 in the growth regulation of these cells [227]. Here, JAK2 is linked to leukemia.