CD44 and cancer: The population of CD44+CD24+ increased significantly in MDA-MB-231 shHMGA2 group (p-Value < 0.05), in contrast with the population of CD44-CD24+, which significantly increased in the Cal-51 shHMGA2 group compared to the scramble group (p-Value < 0.05) (Figure 4E,F) indicating that HMGA2 supports key cancer stem cell features of TNBC.