NOTCH1 and acute myeloid leukemia: In T-cell acute lymphoblastic leukemia (T-ALL) MYC overexpression is driven by a NOTCH1-dependent SE located 1427 Kb downstream of the MYC locus [65], while in acute myeloid leukemia (AML) it is under the regulation of a SWI/SNF-dependent SE located 1.7 Kb downstream of the MYC locus [66].