Conversely, only D-ECM from CRC downregulated the expression of MHC-II and CD86, both markers of proinflammatory macrophages, in monocytes, whereas it upregulated the expression of CD206, a marker used for distinguishing anti-inflammatory/pro-tumoral macrophages from proinflammatory ones (Figure 4). This evidence concerns the gene CD86 and colorectal carcinoma.