CIITA and colorectal carcinoma: miR-146b-5p and let-7i-5p have been shown to target CIITA [50]; moreover, the dysregulation of miR-146b-5p has been documented in a variety of malignances, including CRC [51,52,53], and it has been demonstrated that an increased expression of let-7i-5p is associated with CRC metastasis [54].