Moreover, in order to outline the precise effect of whey and unveil other upregulated proteins in addition to SIRT3, genome-wide analysis applied to in vivo studies, as well as to a largest panel of cancer cell lines overexpressing SIRT3, will deepen the knowledge on the molecular mechanism through which SIRT3 mediates the antitumor effects of whey in CRC cells. Here, SIRT3 is linked to colorectal carcinoma.