NUCLEOLIN and cancer: To suppress the function of oncomiR miR-21, several studies have investigated the anti-cancer efficacy of the anti-miR-21 oligonucleotide loaded in (1) AS1411 anti-nucleolin aptamer-decorated PEGylated PLGA NPs, (2) acid-triggered charge-reversible graphene-based NPs with multilayer polymers, (3) GNPs and (4) chlorotoxin-coupled stable nucleic acid lipid NPs and three-way-junction (3WJ)-based RNA NPs for targeting various types of cancers [104,105,106,107,108].