CD8A and neoplasm: The TME plays a central role in local cancer control by recruiting and differentiating immune-suppressive and/or anti-inflammatory cells, such as regulatory T cells (Tregs), Th17 cells, dendritic cells (DCs), M2 tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), and inhibiting immune effector cells such as NK cells and CD8+ T lymphocytes, which leads to the establishment of an immunosuppressive TME [125].