SHISA3 and nasopharyngeal carcinoma: These data are in line with a study comparing seven EBV-positive NPC lesions and five non-cancer nasopharyngeal epithelium tissues regarding the methylation status of seven candidate genes with known hypermethylated promoter CpG islands and reduced expression in NPC tissues, such as CR2, ITGA4, RERG, RRAD, SHISA3, ZNF549 and ZNF671, demonstrating significantly higher methylation rates of these genes in NPC than in control tissues [114].