Focusing on the 14 samples that were negative for the most frequently thyroid mutated genes, we identified two candidate driver genes (ECD and NUP98) that were not previously implicated in thyroid cancer and recovered other potential drivers previously described in thyroid tumors (LRP1B, NCOR1, ATM, SOS1, and SPOP) [14,15,38] (Figure 2—upper panel). The gene discussed is SPOP; the disease is thyroid cancer.