Lisocabtagene maraleucel (liso-cel) (Breyanzi) is a CD19-directed genetically modified autologous CAR-T immunotherapy FDA approved for the treatment of adult patients with R/R LBCL after two or more lines of systemic therapy, including DLBCL NOS, DLBCL arising from indolent NHL, HGBCL and FL (grade 3B). Here, CD19 is linked to diffuse large B-cell lymphoma.