CD19 and diffuse large B-cell lymphoma: Tisagenlecleucel (tisa-cel) (Kymriah) is a CD19-directed genetically modified autologous CAR-T immunotherapy US FDA approved for the treatment of adult patients with R/R LBCL after two or more lines of systemic therapy, including DLBCL NOS, DLBCL arising from FL and HGBCL.