CD19 and diffuse large B-cell lymphoma: Axicabtagene ciloleucel (axi-cel) (Yescarta) is a CD19-directed genetically modified autologous CAR-T immunotherapy that was approved by the US FDA in 2017 for the treatment of adult patients (≥18 years) with R/R LBCL after two or more lines of systemic therapy, including DLBCL NOS, DLBCL arising from FL, HGBCL and PMBCL.