Inflammatory type ICC accounts for 38% of ICC and is defined by activation of pro-inflammatory signaling pathways via interleukin-10 (IL-10), interleukin-4 (IL-4), interleukin-6 (IL-6), overexpression of other cytokines, and activation of signal transducer and activator of transcription 3 protein (STAT3) (Figure 1) [32]. Here, STAT3 is linked to intrahepatic cholangiocarcinoma.