Here, we demonstrated that WSD-associated factors such as arachidonic acid (AA), Prostaglandin E2 (PGE2), and bacterial toxins LTA and LPS activate pro-inflammatory macrophage and dendritic cell phenotypes to secrete IL-23 for colon tumor progression and also explored an anti-IL-23 approach for prevention and treatment of colon cancer. This evidence concerns the gene IL23A and colonic neoplasm.