Obesity leads to a low-grade chronic inflammatory state and is associated with the increased circulatory levels of pro-inflammatory mediators such as IL-23, IL-17, IL-6, IL-8, MCP-1, TNF-α, and induction of NF-κB and COX-2/PGE2 signaling [7]. This evidence concerns the gene IL37 and obesity due to melanocortin 4 receptor deficiency.