Prostate cancer cells may release factors influencing the balance between osteoblasts and osteoclasts activities (e.g., matrix metalloproteinases, BMP2, IGF1, PDGF, IGFBP3, VEGF, ET1, PSA, WNT, ET1, and TGFβ) toward bone formation [5,16]. This evidence concerns the gene EDN1 and prostate carcinoma.