As indicated in Table S1, PLK1 and its related kinases (AURKA, CDK1, MELK, NEK2) have GD values very close to 1 across all cell lines (irrespective of the type of cancer or whether it is PT or metastatic origin), signifying that the protein products are essential to the survival of cancer cells, thus ideal therapeutic targets. This evidence concerns the gene CDK1 and cancer.