EDN1 and Familial prostate cancer: Prostate cancer cells may release factors influencing the balance between osteoblasts and osteoclasts activities (e.g., matrix metalloproteinases, BMP2, IGF1, PDGF, IGFBP3, VEGF, ET1, PSA, WNT, ET1, and TGFβ) toward bone formation [5,16].