RRM2 and cancer: Other PrCa metastasis-upregulated genes with available inhibitors, but associated with metastasis and invasiveness in other cancer types, are ABCC5 (breast cancer) [50], DGAT2 (gastric cancer) [90], FEN1 (breast cancer) [91], TYMS (multiple cancer types including colorectal cancer) [92,93,94], HTR2B (uveal melanoma) [61], RRM2 (gastric and liver cancer) [95,96], and PNPO (breast cancer) [97].