LAG3 and neoplasm: They result in the production and secretion of growth factors, cytokines and inflammatory mediators by both tumor and stroma cells, the expansion, recruitment and activation of suppressor cells (i.e., MDSCs, Tregs, plasmocytoid DCs), impaired T cell responses, an increased PD-1 and LAG-3 exhausted phenotype; as well as osteoclast activation; and endothelial cell proliferation (e.g., reviewed in [95,96]).