Comparing liquid biopsy from plasma and platelets versus FISH/RT-PCR tests performed on FFPE tumor tissues for the detection of ALK rearrangement and prediction of treatment outcome, it was found that liquid biopsy had greater sensitivity (78.8% vs. 54.5%), specificity (89.3% vs. 78.6%) and accuracy (83.6% vs. 75.5%). This evidence concerns the gene ALK and neoplasm.