The H3Y41 locus may also be phosphorylated by JAK1, thus regulating nearly 3000 proliferation- and survival-associated genes in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), including IRF4, MYD88 and MYC [93] (Figure 2A). Here, JAK1 is linked to diffuse large B-cell lymphoma.