JAK1 and Miyoshi myopathy: In MM, compounds including Icarrin, 3-formylchromone, TM-233, Auranofin, AZD1480, thalidomide analogs and tetracyclic pyridone 6, inhibited upstream JAK1/2, thereby blocking constitutive STAT3 phosphorylation and its nuclear translocation, downregulating downstream STAT3 target genes, such as Bcl-2, Bcl-xl, survivin, COX-2, VEGF, Mcl-1, Cyclin D2 and MMP-9 and inducing programmed cell death [121,122,123,124,125,126,127].