ATRT is characterized by an undifferentiated phenotype with a heterogenous histopathology consisting of varying amounts of progenitor neuronal ectoderm or mesenchymal elements [60,61,62] and expression of embryonic stem cell markers including Sal-like Protein 4 (SALL4), Lin-28 Homolog A (LIN28A), Glypican 3, SALL4, T-cell leukaemia 1 (TCL1) and Undifferentiated embryonic cell Transcription Factor 1 (UTF1) [16,63]. Here, GPC3 is linked to atypical teratoid rhabdoid tumor.