Significant (FDR corrected) pathways identified included Nicotine addiction q = 7.64 × 10−6, Neuroactive ligand-receptor interaction q = 1.01 × 10−3, Taste transduction q = 1.04 × 10−3, Olfactory transduction q = 1.48 × 10−3, ECM-receptor interaction q = 8.33 × 10−3 and the PI3K-Akt signaling pathway q = 1.95 × 10−3 (Table 2). The gene discussed is AKT1; the disease is nicotine dependence.