Furthermore, the whole-genome sequencing and RNA expression data of paired circulating CLL and RT biopsies performed in 17 patients with CLL identified a high number of mutations in poor-risk CLL drivers and genes in the DNA damage response pathway (that seems to be the dominant mechanism driving RT), as well as other genomic aberrations including the protein tyrosine phosphatase receptor and tumor necrosis factor receptor-associated factor 3 in RT biopsies [51]. The gene discussed is PTPRT; the disease is B-cell chronic lymphocytic leukemia.