The first cervical cancer GWAS in the Japanese population failed to identify any SNPs at genome-wide significance, but a second, larger GWAS in the East Asian population (with cohorts from China and Japan), identified and linked their top novel variant rs59661306 on chromosome 5q to the ARRDC3 (Arrestin domain-containing 3) gene, encoding a known tumour suppressor and regulator of insulin sensitivity [119,149,150,151]. The gene discussed is ARRDC3; the disease is cervical carcinoma.