In this process, tumor necrosis factor-α (TNF-α), multiple interleukins (IL), prostaglandin E2 (PGE2) and cyclooxygenase 2 (COX2), and other pro-inflammatory factors derived from tumor stroma activate the intracellular signal, in which NF-κB is the most dominant signaling pathway during this process [17,39]. Here, TNF is linked to neoplasm.