The first signal controls IMCs production, mainly mediated by tumor-derived growth factors, such as IL-6, IL-11, IL-17A, G-CSF, GM-CSF, TNFα, and involves signal pathways including STAT3, IRF8, C/EBPβ, RB1, Notch, adenosine receptors A2b, NLRP3, and others [38,39,40]. This evidence concerns the gene TNF and neoplasm.