A major regulator of YAP/TAZ activity is the tumor suppressive Hippo pathway [96], which consists of a serine/threonine kinase cascade comprised by the mammalian sterile 20-like kinase 1 or 2 (MST1 or MST2), which binds and phosphorylates the scaffold protein Salvador homolog 1 (SAV1). The gene discussed is YAP1; the disease is neoplasm.