POLD1 and neoplasm: Within the irradiated group, we found downregulation of UNG, FEN1, PARP3, POLD, NTLH1, ERCC1 and MPG which are linked to increased DSBs, sensitivity to alkylating agents, impaired tumor growth and reduced EMT, DSB repair and mitotic progression [33,34,36,37,38,39] (Figure 5F).