Ingenuity Pathway Analysis (IPA) of the above-mentioned results revealed that differentially modulated kinases after treatment of volasertib alone or in combination with SOC are regulating glucocorticoid receptor, ERK/MAPK, ATM and AMPK signaling pathways in GBM cells cumulatively involved in glioblastoma signaling and molecular mechanism of cancer (Figure 4H,I). Here, PRKAA1 is linked to glioblastoma.