Previous studies favor a tumor-suppressive function of DIRAS-2 by showing a role in autophagic cancer cell death, similar to DIRAS-1 in ovarian cancer [6], and that DIRAS-2 prevents the interaction of the noncanonical guanine nucleotide exchange factor SmgGDS with other pro-oncogenic, small GTPases, acting similarly to a dominant-negative small GTPase [10]. This evidence concerns the gene RAP1GDS1 and cancer.