Bergom and colleagues more closely analyzed the tumor suppressive mechanisms of DIRAS-1 and showed that DIRAS-1 binds to the noncanonical guanine nucleotide exchange factor SmgGDS (Rap1 GTPase-GDP dissociation stimulator 1 = RAP1GDS1) and acts similarly to a dominant-negative small GTPase [3]. The gene discussed is DIRAS1; the disease is neoplasm.