PPARG and lipoma: By contrast, the pro-tumorigenic role of PPARγ has been reported in a variety of cancers, such as bladder tumor, renal pelvic tumors, hemangioma, lipoma, skin fibrosarcoma, mammary adenocarcinoma, and hepatic tumors, through distinct molecular mechanisms activated by PPARγ ligands regulating cancer cell proliferation, angiogenesis, and metastasis [46].