SYP and adenocarcinoma: In uni- and multivariate analyses (including age, sex, UICC stage, WHO grade), we observed that the MANECs had a significantly shorter overall survival, disease-specific survival and disease-free survival than all synaptophysin-expressing adenocarcinomas, including conventional adenocarcinomas with diffuse synaptophysin expression in more than 30% of the cells of the neoplastic glands.