SYP and neoplasm: After initial statistical analysis (and under consideration of the used WHO threshold) [10], four subgroups of adenocarcinomas were compiled: synaptophysin-negative adenocarcinomas (763/1002), adenocarcinomas with scattered (<1–9% of the tumor cells; 198/1002), partial (synaptophysin expression in 10–29% of the tumor cells; 15/1002, Figure 1) and diffuse (synaptophysin expression in 30–100% of the tumor cells; 26/1002, Figure 1) synaptophysin expression.