In addition to Notch1, a similar pattern of mutations occurs at other Notch genes in several types of hematological malignancies and solid tumors, such as chronic lymphocytic leukemia (CLL) [76], B-cell malignancies [77,78,79,80], triple-negative breast cancer (TNBC) [81], adenoid cystic carcinoma (ACC) [82], and non-small-cell lung cancer (NSCLC) [83]. This evidence concerns the gene NOTCH1 and adrenal cortex carcinoma.