MAML1 and small cell lung carcinoma: Indeed, mutations, occurring at the genes of the γ-secretase component, the co-activator MAML1, as well as the Notch receptors that lead to reduced Notch signaling, have been described in particular subclasses of patients with chronic myelomonocytic leukemia [87], bladder cancer [88], low-grade glioma [89], and small-cell lung cancer (SCLC) [90].