Indeed, inhibition of Notch1 with siRNA or GSI DAPT enhanced growth inhibition and apoptosis induction by doxorubicin in breast cancer cells accompanied with the inactivation of NF-κB, induction of PTEN, and abolishing doxorubicin-induced upregulation of MDR-1 [185,469,508]. The gene discussed is NOTCH1; the disease is breast cancer.