Sustaining this hypothesis, it has been demonstrated that limited pro-apoptotic effects of DAPT treatment in Notch1-expressing gastric cancer cells were at least partially due to ERK1-2-dependent upregulation of Wnt-β-catenin signaling as combined inhibition of Notch and ERK1-2 pathway prevented β-catenin induction and enhanced the efficacy of single DAPT treatment [178]. The gene discussed is NOTCH1; the disease is gastric cancer.