At the same time, even if a monoclonal anti-Notch1 antibody OMP-A2G1 induced apoptosis alone and in combination with docetaxel in an androgen-independent prostate cancer model and suppressed tumor cell proliferation in an androgen-sensitive cell line, there was no additive or synergic interaction between the two agents. Here, NOTCH1 is linked to Familial prostate cancer.