In line with this, paclitaxel induced the generation of tumor-derived endothelial cells accompanied with DLL3 and Notch4 overexpression, and injection of GSI DAPT into xenografts derived from cells previously exposed to paclitaxel decreased the formation of tumor-derived endothelium, affecting Notch4-driven transcription of VEGFR3 [471]. This evidence concerns the gene NOTCH4 and neoplasm.