Additionally, colon cancer resistance to oxaliplatin could be related to the upregulation of JMJD3 and UTX, decreasing the tri-methylation of H3K27 at Notch2 gene and permitting its transcription, whereas the addition of GSK-J4 notably potentiated platinum-drug induced apoptosis [302]. The gene discussed is NOTCH2; the disease is malignant colon neoplasm.