Combination of anti-Notch antibodies (except anti-Notch3) or GSI-XII reverted bone marrow stroma-induced protection of chronic lymphoid leukemia (CLL) cells from the pro-apoptotic action of fludarabine associated with the upregulation of BCL-2 and NF-κB [381]. Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.