NOTCH1 and breast carcinoma: Additionally, other natural compounds have shown Notch-inhibitory potential in various cancer models, i.e., cucurbitacin B, which downregulated Notch1 signaling with consequent reduction of colon cancer growth in vivo and in vitro [366]; diallyl trisulfide, which showed antitumor and anti-inflammatory effects in a model of breast cancer associated with Notch inhibition and the additional advantage of tumor sensitization to doxorubicin [367]; epigallocatechin gallate [368]; genistein [369]; uscharin [370]; oleandrin [371]; and cowanin [372].