In line with the importance of H3K27ac and H3K27me3 in modulating Notch signaling in T-ALL, we have recently demonstrated that both demethylation and acetylation of H3K27 enhanced the expression of Notch3 under the control of Notch1 or Notch3 in Notch-dependent T-ALL [297]. Here, NOTCH3 is linked to acute lymphoblastic leukemia.