In addition, the co-administration of GSI-XII and cytarabine lowered the bone marrow leukemic burden in a murine xenograft model of B-ALL [564], while DAPT reduced central nervous system infiltration in a B-ALL murine model and led to increased chemosensitivity of leukemic cells to Ara-C by impairing their interaction with choroid plexus stroma expressing high levels of Jagged1 and ADAM10 [565]. This evidence concerns the gene JAG1 and precursor B-cell acute lymphoblastic leukemia.