In particular, the tumor sensitization to 5-FU by Notch1 knockdown was mediated through p27 upregulation [548], and inhibition of Notch1 by DAPT affected the 5-FU-chemoresistant population of CRC cells to a higher extent compared with the parental one through targeting the pool of CSC [549]. Here, NOTCH1 is linked to colorectal carcinoma.