NOTCH1 and acute lymphoblastic leukemia: On the other hand, sensitization of T-ALL cell lines to the Wee1 checkpoint kinase inhibitor MK-1775 and enhanced induction of apoptosis were related to the inhibition of Notch1 and not mTOR signaling, indicating that the consequences of combining doxorubicin and indirect Notch inhibitors in the same cancer context may be different [498].