At the same time, simultaneous inhibition of Notch and VEGF signaling with a bispecific antiDLL4-antiVEGF antibody strongly improved tumor growth inhibition by temozolomide in a xenograft model of glioma, providing a possibility to affect both glioma-recurrence associated pathways with the addition of a single agent to chemotherapy [236]. The gene discussed is VEGFA; the disease is central nervous system cancer.