A more eminent effect of combining Notch3 rather than Notch1 inhibitors with doxorubicin in p53-WT HCC may be explained by the observation that Notch1 could prevent AKT-mediated proteasomal degradation of p53 in p53-WT but not in p53-mutated cell lines [504]. Here, TP53 is linked to hepatocellular carcinoma.