Increased cell death of NSCLC cell lines after addition of GSI I and GSI XX to RT was related to Notch1 and Notch3 inhibition mediating MAPK and BCL2 downregulation not accompanied with AKT activation and was further confirmed with additive-to-synergistic values of CI [604]. The gene discussed is NOTCH1; the disease is non-small cell lung carcinoma.