HES1 and malignant colon neoplasm: In colon cancer, oxaliplatin, 5-fluorouracil (5-FU), or SN-38 induced expression of GS subunits that resulted in increased activation of the Notch1/HES1 axis associated with chemoresistance, whereas addition of GSI134 to conventional drugs drastically reduced cell viability through downregulation of downstream survival pathways such as PI3K/AKT.