EP300 and neoplasm: Reasonably, in esophageal adenocarcinoma, in which Notch and NACK play a critical pro-survival role and CBP is highly expressed, combining GSI with p300/CBP inhibitor C646 decreased Notch transcription activity, reduced tumor growth and triggered apoptosis, demonstrating that affecting Notch pathways at multiple levels may be beneficial for tumor growth suppression [319].