However, in SCC, another necessary step in TGFβ-Notch1 induction of EMT is ZEB1-dependent inhibition of Notch3, suggesting that Notch1 and Notch3 may have different cancer-dependent roles in EMT induction and highlighting that the use of pan-Notch inhibitors may not be universally useful [120]. The gene discussed is ZEB1; the disease is cancer.