BCL2L1 and acute lymphoblastic leukemia: The existing evidence of the interaction between direct Notch inhibitors and anthracyclines is limited and ambiguous since the combination of daunorubicin and GSI lacked any additional effects in GSI-sensitive T-ALL cell lines and was antagonistic in GSI-resistant T-ALL cell lines through the upregulation of the anti-apoptotic BCL-xl [444].