DLL1 and breast cancer: Complicating even more the ambiguous interaction between Notch-targeting approaches and etoposide in the above-mentioned cancers, it should be noticed that a forced activation of Notch signaling with hD1R peptide (a DLL1 fragment linked to an endothelium-recognizing part) had a strong antiangiogenic effect and acted additively in combination with teniposide and cisplatin in glioma, breast cancer and NSCLC cells [533].