Zinc finger E-box-binding homeobox 1 (ZEB1) was also found to be upregulated in gefitinib-resistant EGFR-mutant NSCLC patients; clinical studies showed that ZEB1 maintained CSC traits through the regulation of miR200c and BMI1 in a gefitinib-resistant model [75]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.