CHEK2 and colorectal carcinoma: All studies used a multigene panel with CRC associated genes similar to our study, but genes related to other various cancer syndromes not directly related to CRC (e.g., BRCA1, BRCA2, ATM, ATM/CHEK2, PALB2, RECQL5 and CDKN2A, etc.)were also included in three studies.