This is consistent with additional evidence suggesting that NOX4-derived ROS signaling contributes to TGFβ-induced EMT in pancreatic cancer cells through the redox sensor PTP1B [81], as well as the observation that TGFβ cooperates with the redox protein Nrf2 to promote EMT in pancreas epithelial cells [82]. Here, TGFB1 is linked to pancreatic neoplasm.