In contrast, the GPR68 agonist N-cyclopropyl-5-(thiophen-2-yl)-isoxaole-3-carboxamide (Isx) enhances the inhibitory effect of lenalidomide on clonogenicity in MDSL cells, indicating that overexpression and/or activation of GPR68 impacts on the response to lenalidomide in MDS cells. Here, GPR68 is linked to myelodysplastic syndrome.