In our study, in fact, we noticed that this net distinction can no longer be considered, as NDN, for example, were found to express high levels of the immunosuppressive markers CD39 and CD73 [36,46] (Figure 5), and LDN strongly decreased tumor cell proliferation (Figure 6), suggesting that further studies are needed to allow for a full understanding of the role of these different neutrophil subpopulations in cancer. This evidence concerns the gene NT5E and cancer.