Due to this dramatic down-regulation in chemokine receptors’ expression on TANs, we hypothesized that the chemokines binding CXCR2 and CXCR4 (i.e., CXCL1/CXCL2 and CXCL12, respectively) could be responsible for the differential infiltration of NDN and LDN into the tumor. Here, CXCL12 is linked to neoplasm.