Epigenetic alterations are extremely frequent in AML, as a result of somatic mutations in regulators of DNA methylation (DNMT3A, IDH1/2, TET2) and histone acetylation (ASXL1, EZH2), along with translocations involving epigenetic factors (KMT2A fusions). The gene discussed is ASXL1; the disease is acute myeloid leukemia.