Epigenetic alterations are extremely frequent in AML, as a result of somatic mutations in regulators of DNA methylation (DNMT3A, IDH1/2, TET2) and histone acetylation (ASXL1, EZH2), along with translocations involving epigenetic factors (KMT2A fusions). This evidence concerns the gene KMT2A and acute myeloid leukemia.