WNT5A and obesity due to melanocortin 4 receptor deficiency: Recent studies have demonstrated that the pro-inflammatory adipokine wingless-type mouse mammary tumor virus integration site family member 5A (Wnt5a), together with the anti-inflammatory secreted frizzled-related protein 5 (Sfrp5), which both signal via the non-canonical Wnt pathway, play a key role in the pathogenesis of obesity and its metabolic complications [151,152].