Additionally, immune checkpoint blockade via the inhibition of PD1, a protein expressed on T-cells that can be manipulated by tumor cells in order to avoid immune activity, has also led to reduced resistance to MEK inhibitor trametinib and there are currently multiple Phase I and II trials combining MAPK/ERK inhibitors with PD1/PD1L inhibitors in patients with KRas G12C NSCLC (NCT03600883; NCT03600701; NCT02902029) [270]. This evidence concerns the gene MAP2K7 and neoplasm.