LPAR1 and cancer: Integration data analysis identified LPAR1 downregulation (Figure S2E) as the central hub of the network (Figure 4G) whose activity is coupled with G proteins to induce signaling for cell proliferation, cell survival, cell migration, and cytoskeletal changes, and has pro-tumorigenic, pro-migratory, and pro-metastatic effects on cancer cells [46,47,48].