While BUB1, CCNE1, CDC20, CDKN1A, CDKN2A, MCM6, MCM7 and TPX2, played a role in cell-cycle, proteins such as ERBB2, ESR1, L1CAM, PGR, PIGR, PTK2 are molecules involved in the activation cascade that enhance the tumor growth. Here, ESR1 is linked to neoplasm.