On the other hand, high expression of MEG3 is associated with better progression-free survival and overall survival in HGSOC, even though the same authors demonstrated that MEG3 is downregulated in HGSOC cell lines compared to the normal fallopian tube and ovarian cell lines, and upregulation of MEG3 in HGSOC cells leads to inhibition of tumor growth in vitro and in vivo [201]. Here, MEG3 is linked to neoplasm.