In addition, in CRC, during the tumor progression, the amount of NKp44+ ILC3s decreases with a concomitant increment in ILC1s and NKp44− ILC3s [141], thus indicating ILC plasticity [101]; the reduction in NKp44+ ILC3s is also related to tertiary lymphoid structure reduction in CRC [141]. The gene discussed is NCR2; the disease is colorectal carcinoma.