Other tumor types harboring an NRG1 fusion included PDAC, CRC, gastrointestinal stromal tumors (GISTs), squamous cell carcinomas (SCCs), breast, cholangiocarcinoma, thyroid, renal cell carcinoma, bladder, ovarian, neuroendocrine and sarcoma and are clinically actionable oncogenic drivers [17,18,19,20,21]. Here, NRG1 is linked to colorectal carcinoma.