TNF and Insulin resistance: Under experimental conditions that resembled human adipose insulin resistance (differentiated SGBS made dysfunctional by TNF-α exposure), we observed that NMP: (1) selectively restored the expression of metabolic genes impaired by TNF-α; (2) selectively reversed inflammatory changes in gene expressions induced by TNF-α; (3) attenuated TNF-α-stimulated lipolysis and restored cell fat content; and (4) significantly downregulated the adhesion of monocytes to inflamed adipocytes.