Zhang et al. found that Apigenin suppressed cervical tumor growth in vivo by attenuating histamine-induced abnormal estrogen receptor signaling by increasing the estrogen receptor β/estrogen receptor α (ERβ/ERα) ratio when tumor model mice were administered intraperitoneally with 100 mg/kg apigenin +1 mg/kg histamine every 3 d. Here, ESR1 is linked to uterine cervix neoplasm.