It increased Bax/Bcl-2 ratio and mitochondrial outer membrane permeability, caused the release of Cyt c into the cytoplasm, and activated Apaf-1 and caspase 3/9, which induced apoptosis in HeLa cells [114], and it is considered as a potential agent for the treatment of cervical cancer. The gene discussed is BCL2; the disease is cervical carcinoma.