Radha et al. found that tanshinone IIA caused a significant increase in the expression of p53, p21cip1/waf1, pRb and p130, and activated p53-dependent anticancer activity by inhibiting the expression of HPV E6 and E7 proteins, leading to growth inhibition of cervical cancer cells. The gene discussed is CDKN1A; the disease is cervical carcinoma.