Therefore, in this mixed cohort of RA and AS patients, for the first time, we wished to study the effects of one-year TNF inhibition on PON/ARE, MPO the above discussed metabolic markers in association with disease activity, lipids, adipokines, namely, leptin, adiponectin, and chemerin, and vascular pathophysiology including IMT, FMD, and PWV. This evidence concerns the gene PON1 and rheumatoid arthritis.