Moreover, significant interactions between obesity and HLA alleles with regard to MS susceptibility were found, as subjects with a BMI of >27 kg/m2 at age 20 and two risk genotypes (presence of HLA-DRB1*15 and absence of HLA-A*02) had an OR of ~15 compared to nonobese subjects without these genetic risk factors [181]. Here, HLA-DRB1 is linked to myeloid sarcoma.