Interestingly, PV IgG triggers a significant increase in ADAM10 activity in a Src-dependent manner; inhibition of ADAM10 prevents histological acantholysis and skin blistering in mice injected with IgG from PV patients with a typical autoantibody profile, but not with PV IgG containing antibodies to desmocollins [21]. This evidence concerns the gene ADAM10 and acquired polycythemia vera.