Like healthy RBCs, the NDDs (PD, ALS, and AD) cells became less stable against thermal treatment (Figure 5 and Figure 6) and the excess heat capacity cPex of Hb (Figure 5) and B3 protein unfolding (data not shown) in all studied cells that decreased along the aging process. The gene discussed is GSTM1; the disease is amyotrophic lateral sclerosis.