A mixed model of proteinopathies in the brain of patients affected by NDD has been identified [61], showing that in addition to homoaggregates, α -syn, τ, and Aβ interact with each other or with other “pathological proteins” and form toxic heteroaggregates in the brains and peripheral blood cells of patients [4,12,59,62,63]. The gene discussed is TBXT; the disease is proteostasis deficiencies.