In summary, the present study demonstrates that in type-1 diabetic kidney, hyperglycemia results in the downregulation of PPARγ and the upregulation of RXRα, RXRβ and RARγ1, which possibly contributes to elevated PAI-1 levels, and thus, elevated MMP-9 and MMP-13. The gene discussed is MMP13; the disease is Hyperglycemia.